Entering middle age with a muscle deficit increases frailty risk and hinders the ability to maintain physical robustness later in life.

“so I don't really want people entering middle AG with a muscle deficit even if someone comes up with the solution for cancer and Alzheimer's disease and all of these other things you still have to Ward against Frailty you still have to make sure that you enter that marginal decade physically robust and most people don't come close to it they're really really under muscled late in life”