Peter Attia· MD
does it make perfect sense to say that less physical activity makes the muscle less sensitive to uh amino acids
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does it make perfect sense to say that less physical activity makes the muscle less sensitive to uh amino acids
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with physical inactivity you become anabolically resistance
so if we take that previously immobilized leg and we give that person an amount of protein I see a 35% difference between the lag that was previously immobilized and the leg that was not immobilized so there's a 20 35% anabolic resistance after one week of inactivity
so you could take young people who ordinarily would not experience anabolic resistance and you can render them inactive and there's very elegant experiments done where you take young people and you put one leg in a cast for a period of time and the experiment he talked about was one week so this is beautiful because each person is their own control so young person one leg in a cast one leg not and just in one week there was a 35% difference between the active and inactive leg in a young person with respect to muscle protein synthesis and therefore anabolic resistance so again that very compellingly says inactivity plays a huge role
does it make perfect sense to say that less physical activity makes the muscle less sensitive to uh amino acids
anabolic resistance was most exacerbated by inactivity and this was done on the cast study so you take a given individual you cast one leg not the other leg you know before you do that you run the amino acid Isotopes through them you do this exercise for two weeks you take the cast off so you have an atrophied leg and a normal leg you do the same amino acid Isotopes and lo and behold there's like 40% or 50% anabolic resistance on the leg that was in the cast
and a normal leg you do the same amino acid uh Isotopes and lo and behold there's like 40% or 50% anabolic resistance on the leg that was in the cast this is not because they got older in two weeks it's because they were inactive and and they lost muscle activity
anabolic resistance was most exacerbated by inactivity and this was done on the cast study so you take a given individual you cast one leg not the other leg you know before you do that you run the amino acid Isotopes through them you do this exercise for two weeks you take the cast off so you have an atrophied leg and a normal leg you do the same amino acid uh Isotopes and lo and behold there's like 40% or 50% anabolic resistance on the leg that was in the cast
And the experiment that Luke von shared when he was on the podcast I think was a very elegant way to do this which is um they took uh young subjects I don't remember if they were in their 20s but it was thereabouts maybe in their 30s. So very young subjects and they put a cast on one leg, no cast on the other and they left them in this state for a period of time.
We have done some studies where we've used step reduction like abrupt step reduction as a model of, sort of, abrupt sedentarism where we can make older people much more anabolically resistant as a result of that.
I don't think that you can discount inactivity with aging.
physical inactivity may actually be the biggest contributor reducing physical activity worsens anabolic resistance