Heat shock proteins are activated by heat and cold stress, and by sulforaphane, with cold shock activation being less robust than heat shock.

“So for example, one pathway is called heat shock proteins. And as their name would apply, one would go, "Oh, they're activated by heat." Well, correct. They are activated very robustly by heat. But you can eat a plant like broccoli sprouts, which is high in something called sulfurophane. And it activates heat proteins among other things. Cold also activates heat shock proteins. Now, you're going to more robustly activate heat shock proteins from heat versus cold, but there is some overlap.”

“But heat robustly activates them, very robustly. It's good to know that both the hot and the cold are activating some of the same good genetic pathways.”