Discomfort experienced in uncomfortably hot environments is partly due to the release of dynorphins and activation of the sympathetic nervous system.

“Well, first of all, when you get into an uncomfortably hot situation, uncomfortably hot scenario, oh gosh, this is sounding terrible. And a deliberately hot environment that you are using to try and trigger some sort of biological or psychological benefit, I should say, the discomfort that you feel, the desire to get out of that environment, is in part the consequence of the release of dynorphine. It's also the consequence of the activation of that sympathetic nervous system.”

“The sauna or any kind of deliberate heat exposure that's uncomfortable releases this molecule dynorphin. [...] It makes you feel agitated and not good. And then there's this rebound. The way it feels good is later, it causes this upregulation in the so-called mu opioid receptors. So the chemicals that you have, your so-called endogenous opioids, not the opioids that are related to the opioid crisis. But the ones that you naturally make are able to have a more robust effect after the sauna. Dynorphin is an appetite suppressant and for reasons related to kind of general discomfort in the body.”

“I should say the discomfort that you feel the desire to get out of the that environment is in part the consequence of the release of dinorphine. It's also the consequence of the activation of that sympathetic nervous system.”

“there's a very strong effect on bated orphans baited orphans are dumped and also this other system called dine orphan which is you know yeah and and what's interesting is that when you activate dine orphan through the the cap opioid pathway instead of MU opioid you feel uncomfortable”

“When you start getting that "I should get out ASAP" feeling in the sauna That's dynorphin being released And one of the things it does? It increases sensitivity to endorphins (AKA the long-lasting "feel good" effect from the sauna”

“Consequently, repeated sauna sessions may increase mu-opioid receptor sensitivity, amplifying the pleasurable effects of endorphin release in subsequent life experiences.”

“Sauna use could enhance our sensitivity to endorphins, not just by direct stimulation but also by initially making us uncomfortable.”

“When dynorphin binds to kappa-opioid receptors, it triggers a biological feedback that sensitizes the mu-opioid receptors to beta-endorphins.”

“hypothermia from sauna use increases dorphin levels and subsequently endorphin levels even more than exercise alone”

“lastly it also increases the expression of dorphin which sensitizes your body to the Feelgood endorphin”

“when we're talking about the sauna and and Longevity the sauna sensitizes the brain to endorphin and uh it does that by increasing dorphin which makes you feel uncomfortable and uh as a consequence you feel better because you become sensitive to the feel-good Endorphin”

“you are going to feel so much better because that endorphin is going to bind to those receptors that are really sensitive to that endorphin and so the effects are lasting and they last longer and you feel better so it you know your depression is you know it lowers depression it helps with anxiety it helps with all these things”

“heat stress will release dorphin from a pre synaptic neuron and that dorphin will then bind to another receptor called the cppa opioid receptor and when that happens that's when you begin to feel uncomfortable and dysphoric”