Paul Saladino· MD
that's the seed oil story. I'm sorry that was so long. Wow. you were going to go into sugars. Yeah. So the second thing is sugar. The sec sugar drives metabolic dysfunction also but not in the way that we think it does. So this is another interesting story. Sucrose is a disaccharide of glucose and fructose. Glucose and fructose are monossaccharides. Sucrossse is a disaccharide. Starches are polymers of glucose. When you have a fruit, an apple, I gave you guys strawberries downstairs, right? That has glucose and fructose in it. It has sucrose and it has some both of those sugars. That if I give you a strawberry, that doesn't cause insulin resistance in humans. That's pretty clear both at associational or interventional level. If I give you pure sugar, which is pure sucrose that's been refined out of that strawberry, or from sugar cane or from beets, or I give you high fructose corn syrup, which is a another industrial byproduct from corn, or they take corn, which only has glucose, and they isomerize it and they combine it to make a high fructose corn syrup, which is essentially like a fake sugar. If I give you either of those things, it does induce insulin resistance in humans. It's not because it raises your blood sugar. It's because it affects your gut microbiome negatively.