Excess omega-6 fatty acids from soybean oil may damage the hypothalamus, affecting gene expression and the oxytocin system, potentially contributing to obesity and satiety issues.

“the hypothesis here would be that excess omega-6 at least content in soybean oils are damaging the hypothalamus affecting both hypothalamic gene expression uh of all sorts of things and the oxytocin secreting system in the brain and that that may be at the root of much obesity but you do not want to damage your hypothalamus and wouldn't it be scary if many of these seed oils that plant-based advocates would recommend like joel is recommending are damaging the hypothalamus and leading to issues with satiety in many people”