Modafinil, with a half-life of approximately 12 hours, can help maintain wakefulness by activating dopamine and is useful for travel to time zones like Europe.

“I like medapanil medapadanyl has a half life of about 12 hours keeps you awake um through activating dopamine uh in your brain and can be really helpful there's also some newer medications that are really interesting there's one that activates melatonin receptors um it's a melatonin receptor um antagon or agonist um that one's really interesting as well as there's a new one that um blocks oreexin receptors in the brain and the both of those are non-habit forming don't have any of the downsides that a lot of the like benzoazipines ambient things like that have um and actually help um protect sleep architecture so it could be potentially beneficial for uh for travel”