Accumulation of adenosine in the brain is associated with increased sleep pressure, causing drowsiness and promoting the transition from wakefulness to sleep.

“And adenosine works in this beautiful, elegant way, where it will inhibit and shut down the wake promoting areas of the brain whilst also increasing and dialing up the volume on sleep activating, sleep promoting range.”

“Yeah, so the adenosine here that we're talking about that is creating the sleep pressure is a central brain phenomenon. And it comes from the neurons themselves combusting energy. And as they're combusting energy, one of the offshoots of that is this chemical adenosine.”

“But there's really no negotiating the accumulation of adenosine that's going to occur and going to bias you towards feeling more sleepy than you would. Otherwise, that's going to occur throughout the day. There's really no way to eliminate adenosine. All you can really do is block its function.”

“The important point is that adenosine as a pro-sleep molecule is a nonnegotiable aspect of your biology. In fact, it's so nonnegotiable that, every 24 hours, you are going to release adenosine, and you're going to release adenosine in direct proportion to how long you've been awake.”

“adenosine seems to be part or one of the reasons that it builds up is because it's a metabolic byproduct of cellular activity of cellular metabol ISM and it seems to be that the longer that we're awake”

“it seems to be about a 7 to n hour period of sleep is enough time for your brain to jettison all of that adenosine that has been building up across the 16 hours of Prior wakefulness”

“so from the moment that you and I woke up this morning and everyone listening a chemical has been building up in your brain that chemical is called adenosine and the more of it that builds up the sleepier and sleepier you will feel”

“adenosine as it's rising will turn down the volume on the Wake promoting regions of your brain but yet will increase the volume on your sleep promoting regions and by way of this Jewel action that's how it seems to instigate this feeling of sleepiness by temping putting the brakes on wakefulness but hitting the accelerator pedal on sleepiness”

“the longer you're awake the more is the buildup of a molecule called adenosine in your brain and body it makes you sleep sley makes it harder to focus when you sleep adenosine levels are pushed down again you're able to focus again you feel more alert”

“From the moment everyone listening woke up this morning a chemical started building up in your brain called adenosine and the longer that you're awake the longer the amount of clock time that your brain has been awake the more adenosine builds up and adenosine is a chemical that produces what we call sleep pressure and the more of that sleep pressure in other words think of it as sleepiness the longer that you've been awake typically the sleepier that you feel what you're feeling is the weight of that chemical pressure of adenosine now it's not a mechanical pressure in your brain don't worry it's a chemical pressure that's signaling sleepiness the more of that adenosine that there is in the brain the more of that deep sleep that you typically get”

“So accumulation of adenosine in the brain particularly in the basil forbrain is associated with increased sleep pressure that causes you to feel drowsy sleepy and it promotes the transition from wakefulness to sleep.”