Into Rx approaches?: the new DORAS/Orexin antagonists: expensive but they seem to preserve/enhance REM.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Into Rx approaches?: the new DORAS/Orexin antagonists: expensive but they seem to preserve/enhance REM.
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these drugs can improve most all aspects of sleep but including REM sleep which those classic sleeping pills did not
why don't we selectively de develop a drug that goes after this finger that flips the light switch on for wakefulness but now let's block it at night so we flick the switch back in the off position we turn out the lights of the brain and we remove the problem of insomnia which is excessive wakefulness at night
so if you ask me where are we at with REM it's it's certainly more bereft of methods than deep non-rem sleep but we are starting to find some now
there's a new class of drugs that we've spoken about in a previous episode called the Doras the jeel orexin receptor antagonists d r a small s
10 minutes of bright outdoor light within the first hour of waking anchors the circadian phase and improves sleep onset that night.
Morning sunlight exposure shifts the cortisol awakening response forward, improving daytime alertness.
Long-term morning sunlight reduces age-related macular degeneration risk.
Sleep regularity predicts all-cause mortality more strongly than sleep duration.
Tracking deep sleep on a wearable accurately reflects EEG-measured slow-wave sleep.
Caffeine has a half-life long enough that consumption after 2pm measurably degrades deep sleep in slow metabolizers.