Andrew Huberman· PhD
It's well-known that the architecture of sleep is disrupted in depression. What's the architecture of sleep? I've done entire episodes about this, but very briefly in two sentences, although they're probably be run on sentences, early in the night, you tend to have slow wave sleep more than REM sleep or Rapid Eye Movement sleep. As the night goes on, you tend to have more Rapid Eye Movement sleep. That architecture of slow wave sleep preceding Rapid Eye Movement sleep is radically disrupted in major depression.