Apigenin, a chamomile derivative, acts as a hypnotic by activating chloride channels and increasing GABA in the brain, inducing sleepiness.

“And I've talked about a compound, and last time I talked about the mechanisms of apigenin which is a derivative of chamomile, A-P-I-G-E-N, which acts as a little bit of a hypnotic by activating chloride channels, hyperpolarized neurons, increases GABA in the brain, basically makes you feel a little sleepy.”

“And 50 milligrams of apigenin taken 30 minutes before sleep can act as another way to shut off the forebrain and reduce rumination, reduce anxiety, and allow people to fall and stay asleep.”

“But in supplement form, I think I take 50 milligrams about 30 minutes before sleep. And I subjectively experience a better night's sleep, so to speak.”

“the other one is appenine which is a essentially a derivative of chamomile”

“There's another supplement that can be quite useful, which is apigenin. A-P-I-G-E-N-I-N, which is the derivative of chamomile. 50 milligrams of apigenin also can augment or support this kind of creation of a sleepiness to help fall asleep and stay asleep.”