Andrew Huberman· PhD
it seems to be that it's deep non-r sleep that is the principal time when we clear we get the chance to clear away adenosine now now adenosine clearance is happening all of the time it's just that the rate of accumulation when we're awake exceeds the speed with which we can naturally clear but when our brain goes into deep non-rem sleep and becomes less metabolically active it's not as though there's necessarily a more active or a very proactive state of Deep Sleep doing that cleansing it's not it's the same process of adenosine clearance it's just that there is no longer the accumulation that's happening so it gets the chance to catch up on the days adenosine accumulation and then reduce down that adenosine debt and then get you to net net neutral by the morning