Shift work, involving nighttime wakefulness and daytime sleep, is an extreme example of mistimed sleep associated with health issues.

“if we think about the extreme example of mistimed sleep which is shift work you know being awake at night and sleeping during the day you know essentially nobody has that chronotype yeah um but people force it upon themselves and by the way thank you shift workers we need you um you know if I have an appendicitis at 4:00 a.m. in the morning I'm very grateful for people who can help save my life right truckers Airline employees and on and on um nurses Etc parents taking care of kids in the middle of the night that shift work but we know that there are health issues associated with being nocturnal and sleep injuring the day”