A scientific approach to experimenting with sleep supplements involves establishing a baseline, testing the supplement, and then discontinuing it to observe effects.

“I would highly recommend that people explore this issue of dependency and Placebo effects for Sleep supplements on their own and under conditions in which there's nothing pressing the next day that is you don't have a big presentation Etc so what I recommend is that every two weeks or so maybe every month or so take one night off completely from all your sleep supplements or leave out one sleep supplement try to understand to what extent you might have established a dependency either real or Placebo based on these sleep supplements and again I suggest doing this on perhaps a Friday night so that you know it's a weekend the next day so you don't have to work if perhaps you don't sleep well”

“if something does not produce any negative effects then I think you want to try a single ingredient formulation for about a week while not varying anything else not changing anything else in your overall Protocols of nutrition or supplementation I mean it's impossible to clamp everything perfectly from week to week but you know don't change anything else dramatically and just add that supplement for a given week see how it benefits your sleep maybe add in a second second supplement if you like or rather Swap and try a different supplement for a week and then see what works best and see if the combination works even better”

“in my experience there is no problem falling and staying asleep in the absence of a supplement for sleep even if you've been taking that supplement for sleep consistently seven days a week for months and months maybe even years on end”

“again to answer the question is there a dependency established by taking supplements for sleep the short answer is no with the caveat that Placebo effects and belief effects are always going to be at play whether or not you're talking about supplementation prescription drugs or even behavioral protocols for that matter”