A 12-hour time zone shift can be managed with specific protocols including melatonin timing, controlled daylight exposure, and exercise timing.

“Like um for example, the the interventional trial that um that we looked at where it's melatonin, exercise timing, and light exposure in professional athletes. This was like um a study that was a non-controlled study that they did in an Argentinian soccer team, only 22 males, but they basically very specifically gave them a certain amount of melatonin at a certain time of night. They controlled when they got daylight exposure when they got to the location and when they exercised. And they found that the time shift for a 12-hour difference, so this is a 12-h hour time zone difference, that time shift only”