David Sinclair· PhD
The best documented lifespan extension due to spermidine was in fruit flies, which increased 30% In worms & yeast, extension was around 15–25% In mice, there is up to 25% extension of mean lifespan, with lifelong administration
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The best documented lifespan extension due to spermidine was in fruit flies, which increased 30% In worms & yeast, extension was around 15–25% In mice, there is up to 25% extension of mean lifespan, with lifelong administration
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Spermidine, a tiny molecule from wheat germ, protects the heart and extends the lifespan of mice, even when given mid-life.
There's a new study that was really compelling. If you give spermidine to mice, either when they're young or even late in life, they live longer and they have better heart function or other youthful capacities.
Well, we know it extends lifespan of yeast and flies and worms. - And even mice.