David Sinclair· PhD
A 3-month randomized, placebo-controlled, double-blind Phase II trial was conducted with 1.2 mg/day. Spermidine supplementation was apparently safe and well-tolerated in older adults with cognitive decline
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
A 3-month randomized, placebo-controlled, double-blind Phase II trial was conducted with 1.2 mg/day. Spermidine supplementation was apparently safe and well-tolerated in older adults with cognitive decline
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
The one that stands out for me is the one by Schwartz et al., 2018. They were giving people 1.2 grams per day over three months and there was significant enhancement of memory.
A double-blind, placebo-controlled trial finds that supplementation with spermidine, a compound known to enhance autophagy, improved memory performance in older individuals after three months compared to placebo (pilot study).