Elevated LDL levels may not be a reliable sole indicator of cardiovascular disease risk without considering particle oxidizability, such as Lp(a), especially when accompanied by low triglycerides, high HDL, low fasting insulin, and low hs-CRP.

“most humans when they eat more saturated fat and less polyunsaturated fat have an LDL that goes up and some of us have an LDL that goes above 200 which is the the Red Alarm bells in every Physician's office even when we have low triglycerides High HDL low fasting insulin and low hscrp but still our physicians insist that we must go on a Statin lest this this valuable lipoprotein particle kill us dead instantly and then they if you get an oxidized LDL and your LDL is high it is really just a proxy for an elevated LDL which we know is not a good marker of cardiovascular disease risk unless you account for the oxidizability of it like we talked about with the earlier paper when they looked at LP little a”