David Sinclair· PhD
Fact is statins reduce cardiovascular risk by ~25% per 1 mmol/L LDL drop (Lancet, 2010)
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Fact is statins reduce cardiovascular risk by ~25% per 1 mmol/L LDL drop (Lancet, 2010)
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Data from 170,000 people indicates each 1 mmol/L reduction in LDL cholesterol with statin therapy reduces the risk of major vascular events by approximately 25%, regardless of baseline cholesterol levels
suggesting that reduction of LDL cholesterol by 2–3 mmol/L would reduce risk by about 40–50%