The mevalonate pathway produces critical downstream intermediates beyond cholesterol, such as CoQ10, dolichol, and precursors for selenoproteins and vitamin K2.

“Downstream of mevalonate are a lot of intermediates with fancy names that I was never taught about in medical school isopentanol pyrophosphate H gerenal pyrophosphate faral pyrophosphate sine and then a number of other steps to make cholesterol it's important to note that cholesterol itself is a steroid molecule it is a ring structure not a fatty acid fatty acids in the form of triglycerides and cholesterol a ring structure that is a precursor for the critical hormones in your body are packaged into an LDL bus containing AN apob particle apob 100 specifically on the surface as a tag it's a bus with a little tag on the window that says apob b 100 that has other apil proteins on it also that I identifies it as an LDL particle so Statin interrupt that piece of human biochemistry from the outset we must ask ourselves is that human piece of biochemistry important of course it is there are other things made in the mevalonate pathway Downstream from mevalonate that are critical for human health Beyond cholesterol but what I was taught about in medical school was just one co-enzyme Q10 I'll come back to that”