Lowering LDL cholesterol through cholesterol synthesis inhibition may negatively impact organs like the brain, which require cholesterol.

“if you lower LDL through cholesterol synthesis inhibition a lot do you impact other organs namely the brain well you don't know remember when you're measuring whatever LDL metric it's what since floating around your plasma the only place I'll make it irrelevant you know you're not measuring cellular cholesterol based on in LDL cholesterol so you tell me what your LDL cholesterol level is I have really no clue are your cells synthesize and are not synthesizing exporting II fluxing or whatever to particles that carry cholesterol but as I think we indicated earlier on talk today look at his integral sales do have to make cholesterol so you certainly wouldn't want to stop cholesterol synthesis and probably any cell on your body because the cell membranes if nothing else requires it and we talked about the brain certainly the only way has cholesterol as it makes it so if we didn't know we were inhibiting cholesterol synthesis in the brain would you be really that comfortable with that and if you were is there certain limits where oh I wouldn't mind reducing a little bit but how much cuz that brain really needs it and the brain has no other source of cholesterol