Bempedoic acid's prodrug is activated only in the liver, preventing muscle symptoms associated with statins and not increasing glucose levels like high-intensity statins.

“the enzyme to activate it it's only in the liver not in the muscle so it does not have the same reported muscle symptoms that have been seen with statins and also interestingly it doesn't seem to have the risk of nuance diabetes or the increase in glucose that we see with high intensity statins”

“the difference is bidic acid is less potent than a Statin um and more selective in that way”

“the final drug so we can just wrap this up because I'm sure the listeners are tired of hearing about this stuff uh is a is a drug called bidic acid that is a prodrug so it's a very elegant drug uh it's taken as a pill uh but it's ineffective until it's metabolized by the liver and in the liver it then inhibits um cholesterol synthesis what makes this drug special is unlike statins this drug only works in the liver so statins work throughout the body they do most of their work in the liver but technically every cell is impacted by a Statin only hepatocytes are impacted by bondic acid and it lowers apob same way lowers cholesterol synthesis liver says I need more cholesterol puts more LDL receptors up pulls”