Lowering serum LDL cholesterol to 40-50 mg/dL may be unsafe and lead to psychiatric events, suicides, homicides, and mood disorders. — Whalespan
Lowering serum LDL cholesterol to 40-50 mg/dL may be unsafe and lead to psychiatric events, suicides, homicides, and mood disorders.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“i'm not convinced your body does have enough cholesterol when you inhibit hmg clay reductase and i would debate tom day spring or peter to that any day of the week i'm just not sure that looking at the total pool and saying oh there's so much more in the cell membranes than there is in the lipoproteins means anything about how much your body needs and really gives any sort of a safety profile for lowering your serum ldl cholesterol to 40 or 50 milligrams per deciliter like you might do with a statin and a pcsk9 inhibitor”