Drug mechanisms proven to safely reduce cardiovascular events by lowering cholesterol involve enhancing LDL receptor expression or clearance.

“as long as I can enhance LDL receptors by the way which is pretty and primarily the only pathway that's ever worked with drugs to reduce clinical events safely is expressing in one way or another more LDL receptors statins ezetimibe all S&C questions pcsk9 inhibitors it's a very important point to make what you're basically saying is the only drugs that have ever shown to both reduce cholesterol but more importantly reduce events have either been in isolation or in compounds or in combination where they are enhancing clearance”