We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
so don't ever let a patient stop because they've doubled their ast whatever amination measuring level on statin not related to anything you got great medically little safety because that's what the guidelines are telling you to do
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I would chip in its CK elevation has nothing to do with statin toxicity or stand so this silly biomarker totally first of all before you ever do that make sure you have a baseline just because a lot of people just working organs not even working out they just have high CK that's african-american so so but I don't realize that and you know when you should stop a statin want to see one is like a 10,000 fold elevation of CK and you might start to worry so seek and there's any number of guidelines you shouldn't say it's not a biomarker those of any use to you and all you do by doing CK is when somebody goes from 50 to 300 they get the bejesus scared out of them and they stop their statin when there's no reason the reason you should stop a statin is if they're having Maya Pathak symptoms aches or weakness then I don't care what they're seeking I'll get some info to you on ways of monitoring CK and if they come in and tell you hey Peter I'm feeling pain or you somehow are doing some muscular strength testing or they tell you I don't get out of the chair as much proximal muscle weakness stop the dawn yeah
there's not a package insert in the world that tells you you should even be following a minase to judge statin or anything going on in a liver as a result of a statin there's no correlation whatsoever so I'm repeating them and all the time because maybe as a biomarker of fatty liver or something else but not a statin toxicity it's not you know so don't ever let a patient stop because they've doubled their ast whatever amination measuring level on statin not related to anything you got great medically little safety because that's what the guidelines are telling you to do there's not a statin in the world that they're all out of the package insert that you should be following liver function tests