Unlike ApoB, which undergoes lysosomal degradation leading to therapies like statins and PCSK9 inhibitors, ApoE largely escapes degradation and recycles back into cells.

“one fundamental difference between apob and apoe is that apob once it's taken up by a liver cell typically goes and gets a lysosomal degradation pathway and that biology by goldstein and others have led to therapies including statins and later pcsk9 inhibitors because apob can get degraded in the lysosome and if you can figure out how apob is degraded you can make a medication now one fundamental difference about apob from apoe is that apoe to a large extent escapes degradation and once it's taken up by a liver cell or an astrocyte or a neuron it recycles back”