The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And there's this little molecule in between at the time, most people would point to TSC2. Well, turns out AMPK activation is fine. If you activate mTOR, has no bearing on AMPK, but if you activate AMPK, it's going to activate TSC2, which inhibit mTOR.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
what one of the things you'll notice is mtor and akt don't really influence mpk but there is some literature that years ago showed mpk will activate another protein called um tsc2 and that will actually inhibit mtor and that was the first molecular explanation for the quote unquote interference effect of endurance training on hypertrophy
it makes sense from a teic perspective that if you don't have excess energy you know this remodeling is extremely energy expensive why would we want to create more of it if we don't have the energy to support it