Metabolic stress plays a role in muscle hypertrophy.

“And this is metabolic stress is the burn, right? It it's there. So, you want to train to failure, but you don't need to go to extreme failure.”

“One of the things we do think matters is uh metabolic stress so this idea that you're accumulating these metabolic byproducts inside the muscle as you work it out so that kind of like the bfr the the pump right um that does appear to have some decent mechanistic data to support it like in terms of you know hydrogen ion accumulation how that may affect uh some you know signaling uh those sorts of things even right down to like calcium release into the cylas”