Peter Attia· MD
the the the sort of assumed belief was anytime muscles got bigger they were getting bigger in the contractile units correct
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the the the sort of assumed belief was anytime muscles got bigger they were getting bigger in the contractile units correct
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I see that's amazing we don't know the answer to that question yet we don't more data have started coming out wow but even a few years ago the the idea that sarcoplasmic hypertrophy was a thing was thought of as like garbage bro science meaning the idea the the the sort of assumed belief was anytime muscles got bigger they were getting bigger in the contractile units correct by the way I'm not I'm not I'm not shocked that that was the default hypothesis I'm shocked that it wasn't definitively known he was a it was a technology issue okay is an assay problem like figuring out how to actually measure this
there's actually interesting work we actually have some tissue on its way to Auburn right now because one of the things that's been interesting it's like a Bro Science thing for years of sarcoplasmic hypertrophy versus contractile hybrid and so what this is really positing is is the change really coming from fluid retention basically or is it actually an enhanced of the contractile tissue which in this case would be an uh actin and myosin um seems to have some initial work there that's a little bit of both and it happens to different phases of training
or if that hypertrophy was coming simply from excessive fluid and not actually contract then you would actually have a larger muscle and um when I say fluid ret I'm not talking about like acute fluid retention I'm not saying like you're bloated today you've water loaded I mean just there's there's enhanced fluid and a homeostatic balance inside the tissue because diameter has gotten larger but it wasn't met with an equal amount of increase in contracti units so if that number gets off yeah I think another physiologic Point that's worth explaining to people is how much people are familiar with the idea that 2/3 to 70% of our weight right I stood on the scale this morning like that number on the scale twoth thirs to 70% of it is H2O yeah and then people say okay well wait how can that be because I get that my blood plasma is water that can't be where it all is no most of it is in the cells of our body and the muscle is of course no exception given that it's such a ubiquitous cell totally and in fact given that it occupies the vast majority mass in your body yeah so giving the fact that that in order for it to store its primary unit of energy it needs to bring water with it being glucose [Music] right