Stress hormones like glucocorticoids and norepinephrine can increase the energetic cost of cellular life through an allostatic response.

“We've done experiments in cells in a dish. you give cells uh gluccocorticoids like a cortisol mimedic or norepinephrine >> and then we wanted to know how much energy does it cost right to to mount a stress response like those hormones are not damaging by themselves but if you give them to cells the those cells go into like uh a whole choreographed respon evolutionary you know ingrained response that prepares them for the future right it's called alostostasis uh and that cost a bunch of energy”