Paul Saladino· MD
The only potential benefit to these compounds is hormesis which is a philosophical idea that potentially a small amount of a toxin could result in increased uh enatic systems like the Nrf2 system and increased glutathione
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The only potential benefit to these compounds is hormesis which is a philosophical idea that potentially a small amount of a toxin could result in increased uh enatic systems like the Nrf2 system and increased glutathione
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it turns on the nrf2 or the nerf to pathway in the liver which is our sort of generalized pathway for creation of antioxidant molecules
plant compounds molecules and plants can activate antioxidant response elements in our body they do this because they are a toxin okay and this is I'm sure that dr. Sinclair and he and I were talking actually before the podcast cuz I bumped into him outside I'm sure he would agree with this like the things that we think of as II know our medics our toxins so the dose makes the poison as people say about hormesis if you give yourself a small amount of a molecule like sulforaphane which is in broccoli sprouts right this is an isothiocyanate molecule it will activate the nrf2 system in the liver and the nrf2 system in the liver will say okay I need to make more glutathione I'm gonna turn on glutathione so Faye's glutathione peroxidase and you'll get more included I own glutathione is the major cellular antioxidant currency in the body okay so you will increase your glutathione in the short term with an isothiocyanate like reza like so farthing