Supplementation with 1000mg of lion's mane or 500-1500mg of chaga mushroom per day can act as adaptogens by reducing cortisol and interleukin-6.

“That said, there are good data showing that 1,000 milligrams, that is 1 gram, of lion's mane per day and/or-- I will talk about the end/or portion in a moment, and/or chaga mushroom at 500 to 1,500 milligrams per day can act as adaptogens in, again, reducing cortisol. But also and mainly reducing some of the anti-inflammatory cytokines that are known to circulate in high abundance when you're under a lot of psychological and/or physical stress. Things like interleukin 6 and some related molecules.”