Methodological flaws in studies cited by the 'Enough is Enough' editorial include lack of quantitative biochemical analyses, inadequate dosing, excessive dosing, and inclusion of individuals in advanced disease states.

“most of the studies lacked any quantitative biochemical analyses of vitamin and mineral concentrations in plasma or blood cells at Baseline which is before the trial started or at followup which is after the treatment problem number two many individuals in some of the studies were severely deficient in a particular vitamin and mineral and after the treatment they were still deficient in this particular vitamin and mineral which suggests that the dose of the vitamin and mineral supplement was inadequate problem number three in some of the studies excessive amounts of vitamins and minerals were given problem number four in some of the studies individuals were in a severely Advanced disease state”