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Rapamycin extends mouse lifespan 9–14%
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Rebuttal to Anti-Vitamin Editorial: "Enough is Enough" — Whalespan

Content›Video›Rebuttal to Anti-Vitamin Edi…

Rebuttal to Anti-Vitamin Editorial: "Enough is Enough"

Rhonda Patrick15m · 2014-02-01

Claims Made

31

Claims Supported

10

Support Rate

32%

Support rate

10 of 31 claims supported

10 supported21 partial / not

Claims from this content

24

◐Partially SupportedVitamin D3 is converted into a steroid hormone that regulates approximately 5% of the human genome, including immune function.◐Partially SupportedAdequate folate levels can prevent cancer, while inadequate levels can damage DNA.✕Not SupportedMany clinical trials fail to measure micronutrient levels before and after treatment, potentially leading to inaccurate conclusions about supplement efficacy.✕Not SupportedThe 'Annals of Internal Medicine' published a flawed paper suggesting vitamin and mineral supplements are ineffective and harmful.Partially Supported

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Rhonda Patrick on Sauna Use

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

A study showed a positive effect of daily multivitamin use on cancer incidence in men but not women because women in the treatment group had identical or even higher concentrations of certain minerals compared to the placebo group, indicating inadequate dosing or lack of compliance in women.

✕Not SupportedMethodological flaws in studies cited by the 'Enough is Enough' editorial include lack of quantitative biochemical analyses, inadequate dosing, excessive dosing, and inclusion of individuals in advanced disease states.

◐Partially SupportedA study on long-term multivitamin supplementation and cognition in men over 65 lacked quantitative biochemical data, making it difficult to assess the multivitamin's effect on cognition.

✕Not SupportedMany people in the United States have dietary inadequacies of vitamins and minerals.

◐Partially SupportedA study requiring subjects to take six high-dose multivitamin pills daily for 4.5 years without biochemical data makes compliance difficult to ascertain.

◐Partially SupportedVitamin and mineral supplementation is correlated with addressing dietary inadequacies.

✕Not SupportedExcessive levels of folic acid or vitamin A in individuals with cancer can accelerate cancer progression.

◐Partially SupportedFolate is essential for DNA synthesis and repair, including the incorporation of thymine into DNA.

✕Not SupportedIndividuals at high risk for lung cancer should avoid high doses of vitamin A supplementation as it can accelerate carcinogenesis.

◐Partially SupportedCancer cells utilize folate for new DNA synthesis to fuel their rapid proliferation.

◐Partially SupportedTwo studies on multivitamin use and cardiovascular diseases lacked biochemical data to assess compliance or effects.

◐Partially SupportedInhibition of folate metabolism is a recognized chemotherapeutic target for killing various cancer types.

◐Partially SupportedIn smokers, high doses of vitamin A supplementation can accelerate cancer due to carotenoids being cleaved into DNA-damaging products in the oxidative lung environment.

◐Partially SupportedMany adults in the United States have inadequate dietary intake of vitamins and minerals.

◐Partially SupportedDietary inadequacies in vitamins and minerals can cause cancer, but supplementation can be complicated if cancer is already present, necessitating an understanding of mechanisms.

◐Partially SupportedMultivitamin use showed no effect on plasma vitamin and mineral concentrations in women, and sometimes the placebo group had higher concentrations.

◐Partially SupportedNumerous studies demonstrate that vitamin and mineral supplementation can prevent cancer and cancer metastasis.

◐Partially SupportedSupplementation with vitamin C and E reduced the incidence of atherosclerotic lesions, corresponding to increases in plasma levels of vitamin C by 72% and vitamin E by 90%.

◐Partially SupportedVitamin A is converted to retinoic acid, a steroid hormone that regulates gene expression and is important for immune system function against cancer cells.

◐Partially SupportedA study on vitamin D supplementation showed the treatment group had serum levels of 39 ng/mL compared to 30 ng/mL in the placebo group, with both considered adequate, making conclusions about cognitive effects difficult.