We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
Do note that things like citrulline and arginine can have some side effects if you will. They can increase the likelihood of having herpes cold sore outbreaks on the mouth. The arginine is in the pathway by which I don't know if people know this, but the herpes virus lives on neurons of the trigeminal nerve that innervates the lips and the eyes and the mucus membranes of the face.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
for those of you that are interested in citrine or or beetroot because they are in the Arginine pathway if you're somebody who has um a predisposition to cold sorce um oral cold sorce that is or other forms of cold sores that um because activation of the Arginine pathway can exacerbate some of the neural related aspects of of cold sores and that's because the viruses that cause those cold sores actually live on neurons then you want to be very cautious with citrine especially high dose citrine I can really amplify that the cold sore response
Now you said arginine's fallen out of favor. Why? Why is that? Okay. So like you're probably pretty aware of nitric oxide metabolism. You can't just consume nitric oxide nitrite nitrate like immediately like you're toast, right? So then the argument is oh can we go back up the chain like can we go up to arginine? Can we go back up the thing? So the first stop on that train was arginine. Uh and then the issue you're going to fall out there which is almost always the case with supplementation was bioavailability. Like how can we just get enough of it? And that one just seemed to fail. uh well just it seemed to get better once we started going there. And then there's other concerns uh cold sores and things like that started popping up that people were like not super stoked about and so citrine seems to be the better approach that right now that's the short version.