SAMe has shown comparable efficacy to Naproxen for pain relief at certain doses, though it may take longer to produce effects.

“SAMe in particular has been interesting because it's been shown head to head with drugs like Naproxen and other drugs of that sort, which are well established and sold over the counter in the US to work at least as well as some of those compounds at certain doses. But it's also shown that SAMe and some of those things take more time in order to have those effects. In fact, head to head with things like Neproxin have been shown that they can take up to a month in order to have the pain relieving effect.”