Augmenting dopamine levels can increase pursuit of dopamine-releasing activities and the pain of lack of accomplishment.

“if you're starting to augment the amount of dopamine increase the amount of dopamine through things like supplementation and prescription drugs what's gonna happen is you're not only gonna need to pursue more and more of the sorts of things that are associated with the dopamine. So more doing more studying, more sport more pursuit, higher mountains, more money, more whatever but we know that over time, the mirror image of that the pain of lack of accomplishment will also increase.”