Supplementing with methyl folate and methyl B12 can lower homocysteine levels, potentially reducing ADMA/SDMA and increasing nitric oxide synthesis, which may benefit vascular health.

“we know that if you take methyl folate and uh uh methyl B12 you're going to lower homocysteine that's abundantly clear so the the thinking is that that might actually lower um adma sdma and raise nitri oxide synthes again relatively low cost lowrisk you know thing to take at modest doses”