Andrew Huberman· PhD
one way to prevent the increase in TMAO, if you're taking Alpha GPC at all is to take 600 milligrams of garlic because it contains something called allicin.
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one way to prevent the increase in TMAO, if you're taking Alpha GPC at all is to take 600 milligrams of garlic because it contains something called allicin.
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Now I've been taking Alpha-GPC pretty consistently for a number of years. I do not take it every day. I would say I take it about four days per week, again, prior to workouts or bouts of cognitive work. I have not seen my TMAO spike and I've evaluated that by way of blood tests, but nonetheless, I take 600 milligrams of garlic in capsule form anytime I eat anyway and I do that for general cardiovascular function and there's some interesting data on immune system function, et cetera for garlic. So I've been consuming 600 milligram capsules of garlic for some period of time. Some days, I'll ingest just one 600 milligram capsule, other times, I'll take two, but based on this recent study and the concerns about TMAO, I make it a point to always ingest a 600 milligram capsule of garlic anytime I take Alpha-GPC, which again for me is about four days per week.
But it can also increase TMAO, which is a kind of a negative marker of cardiac health and cardiovascular health. For that reason, I and many others will take 600 milligrams of a garlic capsule, which can offset that TMAO increase.