Andrew Huberman· PhD
However, there were very specific dosage regimens that were described there and duration of treatment. And so you should not take anything that I say or that study to mean that you can just take this stuff willy-nilly or at any concentration of course, or dose. You always want to pay attention to what the science says. That paper fortunately is freely available online. And we will also provide a link to that study. For those of you that are interested in SAMe and its usage for the treatment of various types of pain, and perhaps other benefits, a number of companies have stopped making SAMe instead what they're now focusing on is what they think is a better or more bioavailable alternative, which is 5-methyltetrahydrofolate or 5-MTHF. This molecule is necessary for converting homocysteine to methionine, which is then converted to SAMe so rather than taking SAMe directly, the idea is to take something that's upstream of SAMe and make more SAMe endogenously available.