Andrew Huberman· PhD
My understanding is that taking a low dose more frequently is going to be more beneficial than the kind of old school way of giving 100 or even 200 milligrams in a single injection once every two weeks. Is that right?
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My understanding is that taking a low dose more frequently is going to be more beneficial than the kind of old school way of giving 100 or even 200 milligrams in a single injection once every two weeks. Is that right?
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I would assert with near certainty that you are not optimizing your hormone status if you are and when I say optimize I mean just like dialing in the stability of it and the side effect profile and potentially quality of life as much as you could if you did a more frequent schedule especially with an antidate.
And I would say that two times a week, at least for somebody seeking good quality oversight, you know, preventative medicine, whatever, if they're coming to you or to somebody who believes in the same things you do, twice a week, I think, is kind of minimum for decent, steady hormone concentrations.
In general, once a week is like bare minimum, I would say, but that's certainly not optimal. And I would say that two times a week, at least for somebody seeking good quality oversight, you know, preventative medicine, whatever, if they're coming to you or to somebody who believes in the same things you do, twice a week, I think, is kind of minimum for decent, steady hormone concentrations.
one week to twice a week, like I'd say there's a pretty dramatic difference that's worthwhile to Y.
Which suggests to me that the bigger the the higher the peak, the more the FSH LH suppression.
So the more frequent you get there's a diminishing returns for sure but you can lower the aromatization spike and five alpha reduction by going more frequent.
in general once a week is like bare minimum I would say but that's certainly not optimal and I would say that two times a week at least for somebody seeking good quality oversight you know prevented medicine whatever if they're coming to you or to somebody who believes in the same things you do twice a week I think is kind of minimum for decent steady hormone concentrations
maybe it's more reasonable to expect them to pin more frequently say pin I mean inject but there is a halflife associate like with the drug depending on the Ester chosen
the more frequent you get there's a diminishing returns for sure but you can lower the aromatization spike and five Alpha reduction by going more frequent so if you have a Bess administration of I don't know 150 milligrams once a week you are literally spiking your tea into Super physiological territory acutely and concurrently you are getting super physiologic conversion to estradi DHT
I would assert with near certainty that you are not optimizing your hormone status if you are I want say optimized I mean just like dialing in the stability of it and the side effect profile and potentially quality of life as much as you could if you did a more frequent schedule especially with an anth so once a week is a little bit meaning you you you the more frequent you're giving it the better
I think the best way to conceptualize for The Listener too why this frequent protocol or getting a more stable level is even why is it result in a lower side effect burden too it's the most the closest you can replicate natural function the more you will replicate natural side effect profile which you know should be nothing if you were a physiologic so with you know nesto which is like in and out acutely like so fast you were not getting this huge Spike to like you know 1,500 2,000 nram per deciliter total T there is no situation ever in which your testes would just blast you once a we with a hammer of test and all of the associated metabolites and backand and consequences of that you would have little pulsations over you know a dial Rhythm and this is why you you know you would test your blood as a natural in the morning when your testosterone is spiking and it's going to EB and flow over the day your test level in the morning will not could be 300 nanograms per deser higher than later in the day like it fluctuates so to expect that it's reasonable to jam yourself with an CD amount of test in one go and then hang on that as it declines at your body and then crank it to the stratosphere again once a week it's just an not representative of a physiologic state whatsoever so the more you can replicate that dial Rhythm through the synthetic Administration route the closer you're going to get to a lower side effect burden
so typical dose would be somewhere between 80 and 100 milligrams of testosterone a week so it would be 50 40 to 50 milligrams twice a week and that produces just a much more steady uh level cuz you're you're really trying to get the steadiest level possible
But the reflection of that in blood work is you would typically see because you're bless dosing it at once, your blood work would shoot into supra range depending on the total dose of course, but like a lot of people this is what happens. they shoot into like I don't know 13004 1500 1500 total T with the proportional five alpha reduction to DHT suppression of SHBG disproportionate freeing of free androgenic signaling via more DHT being free than would otherwise be normal more free tea than is proportionately normal more aromatization than would be possible if that dose was like even spread out on an even curve throughout the week on micro injections increase in ariththropoesis acutely beyond physiological you know, capacity to, you know, an unhealthy acute level at least for a periodic period of time and then you're in like a slow or steep depending on like the estester crash essentially into like sort of normal looking territory until your next shot.