Peter Attia· MD
these were not designed for women I can tell you that the data in Australia is very positive for example I worked very closely with the one of the main researchers there a woman named Susan Davis who's done a lot of the work um in this field both in Australia and worldwide and and is a first author on a number of really important testosterone consensus papers she um impresses me but what she tells me about the clinical outcomes and the ability to get kind of steady state good blood levels because it's a controlled product designed for women regulated and formulated we need that that said you do have to follow levels mainly to make sure that you're a achieving safe doses right y so like if you said to me well like let's say someone has a level but it's too low and they're not getting benefit um would you go up and i' say sure because we haven't achieved the physiologic range and I know it's still safe so I am like checking it to make sure they're if they're not having symptoms that are improving to see that we're giving them enough but the most important reason for monitoring blood levels and I monitor for because of what you explained the smartest thing is just to men a total te right it's not a so we we didn't go through this in elaborate detail it's not clear that that's the best marker for knowing whether that's the way to tell whether testosterone is helping a patient in their cells and in their brain right their genital cells their brain and some other body cells too right but that's probably the grossest best measure we have because T fre is calculated and we don't even know if that's the bioactive component yeah testosterone it's a very complex what now is called iny it hits the cells it gets converted into metabolites um Androgen DHT it enters the cell through the Androgen receptor and has both genomic and non- genomic effects non-genomic means direct action genomic means it causes Gene translation other protein development which then has trophic effects right and so all of that's happening