Bryan Johnson· Author
I will start with a weekly dose of 0.5 mg, that is 1/2 the typical microdose, and 1/5 of the typical starting does for type-2-diabetes or weight loss (17).
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
I will start with a weekly dose of 0.5 mg, that is 1/2 the typical microdose, and 1/5 of the typical starting does for type-2-diabetes or weight loss (17).
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I microdosed Tirzepatide (0.5mg/day) and it increased my RHR by 3 bpm and lowered my HRV by 7.
Tirzepatide: +1.5–3.5 bpm
interesting to see my microdose at 0.5 mg/week showing similar side effects.
The increase in my RHR decreased my HRV by 7 points, and decreased sleep quality by 10%.