The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
why do you think the fibrates work best in patients with a higher triglyceride level because their main mechanism of that looked so they modulate HDL particles but triglycerides and has a lot to do with HDL remodelling too but fibrates mostly stop the synthesis of the LDL particles triglyceride rich LDL particles in the liver by depleting triglyceride pools in the liver
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so vibrates through several mechanisms one you get is an enzyme involved with the synthesis of triglycerides you know it's adding fatty acids to glycerol fibrates are a potent inhibitor of that so you use you just stop triglyceride production with fibrates omega-3 fatty acids work in a similar way so they deplete the hepatic pool of triglycerides and you're gonna make less VOD l particles
one you get is an enzyme involved with the synthesis of triglycerides you know it's adding fatty acids to glycerol fibrates are a potent inhibitor of that so you use you just stop triglyceride production with fibrates
I remember a fiber he's not gonna blow away your LDL P like a statin does but it's gonna blob a 10-15 percent reduction in part depending on the triglyceride richness not the serum triglyceride level but the Tri goes from the richness of the core