A study is planned to analyze muscle biopsies using Ouroboros and Seahorse machines to assess mitochondrial density and respiration, and to investigate metabolic pathways, genomics, proteomics, and metabolomics to identify dysregulated mechanisms in individuals with metabolic syndrome, type 2 diabetes, and healthy controls.

“We're going to be looking at the muscle biopsy mitochondrial density. respiration. We have two different machines, the Ouroboros and Seahorse. How many subjects are you looking to recruit? Well, so far, we want to have about 50. We're going to be recruiting people who are well-trained... Then we're going to have also more really active individuals who are healthy. Then we're going to have another group that is master's athletes... And then we're going to be looking at pre-diabetics and type 2 diabetics. And we're going to be looking at mitochondrial function, mitochondrial respiration, genomics, proteomics, metabolomics as well, and try to find the exact mechanisms that go wrong.”