Intermittent hypoxic-hyperoxic training (IHT) can improve blood glucose control in prediabetic individuals, reducing fasting blood glucose and improving 2-hour OGTT blood glucose levels one month post-protocol.

“Sustained improvements in blood glucose control: Participants: 7 healthy amd prediabetic (aged 44-70 years) Protocol (IHT, not IHHT): 3 weeks, 3 sessions per week Session structure: 4 cycles, each consisting of 5 minutes of 12% O2 breathing followed by 5 minutes of room air breathing. Key findings Prediabetics Reduced fasting blood glucose by an average of 6% (0.4mg/dL) one month after the protocol ended. Improved blood glucose control, with a 2-hour OGTT blood glucose reduction of 13% at 1 day and 23% at 1 month post-IHT. Healthy participants: Trend towards improved glucose tolerance, with reductions of 6% at 1 day and 8% at 1 month post-IHT (statistically insignificant).”