Nicotine's alteration of brain chemistry can lead to addiction to other substances and vaping-associated behaviors.

“And of course there are nicotine patches, nicotine gum, there's nicotine in pill form, there are toothpicks dipped in nicotine, et cetera, Today we are going to separate our discussion of nicotine from a discussion of smoking and vaping and the other forms of delivery for nicotine. We will be talking about smoking and vaping and other routes of nicotine administration, both for sake of highlighting their detriments to health and, believe it or not, in certain cases, keep in mind very specific certain cases, the possible health benefits of delivering nicotine through specific modalities. Turns out those modalities do not include smoking cigarettes or vaping. And we are going to pay particular attention to vaping today because vaping use is on the rise, in particular in young people, and vaping use, and the fact that most tobacco that's consumed through vaping includes quite amount of nicotine has created a scenario where nicotine because of its ability to change certain chemicals in the brain can actually lead to addiction for a number of other substances related to vaping and vaping associated behaviors.”