Ingesting substances that powerfully modulate the dopamine system with rapid kinetics in young people can lead to impaired dopamine reward systems that may become permanently impaired without deliberate intervention. — Whalespan
Ingesting substances that powerfully modulate the dopamine system with rapid kinetics in young people can lead to impaired dopamine reward systems that may become permanently impaired without deliberate intervention.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“I'm very concerned about a practice of ingesting something that powerfully modulates the dopamine system with the sorts of kinetics that one sees from ingestion of crack cocaine in young people that has all these other negative health effects that in the short term is very powerfully rewarding, increased focus, wellbeing, et cetera, but that over a very brief period of time leads to a state in which the entire dopamine reward system is impaired and can become permanently impaired unless one intervenes in a very deliberate way.”