Andrew Huberman· PhD
And in the case of vaping, there's a very rapid increase in blood concentrations of nicotine, much faster than occur with cigarette smoking or other modes of nicotine delivery.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
And in the case of vaping, there's a very rapid increase in blood concentrations of nicotine, much faster than occur with cigarette smoking or other modes of nicotine delivery.
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One of the major important differences between vaping and cigarette smoking is that the onset of dopamine release from vaping is faster. And even a subtle increase in the rate at which dopamine increases in the mesolimbic reward pathway can make a given amount of nicotine much more habit forming and addictive.
Now this probably explains the fact that many, many more people, in particular, young people age 25 and younger are vaping at phenomenal rates.
The reason why vaping and crack cocaine are so similar is the speed of entry of nicotine into the bloodstream.
both crack cocaine and vaping cause very rapid increases in the relative substances that are psychoactive, in the case of cocaine, that would be cocaine and the increase in dopamine in the brain and body I should mention.