Paul Saladino· MD
i think that i i agree with you that that you know retinol palmitate is the form that's in liver and retinal palmitis and many supplements there's also retinal acetate which is a water-soluble form of vitamin a much more likely to result in toxicity but if we're looking at the fat soluble forms retinol palmitate and liver retinol pulmonary supplement are probably pretty equivalent and there seems to be a pretty reasonable safe zone for people and you know if you eat massive amounts of liver from a cow you could probably accumulate too much and if you eat a polar bear liver or other carnivorous animal's livers you might be able to accumulate too much but i think that my position continues to be that moderate amounts of liver uh you know a few ounces a week is totally fine and safe the desiccated supplements are nice because they don't have a ton of liver but they have enough to provide nutrients folate and riboflavin that we know are important for people with mthfr polymorphisms and other biochemistry in all of us i also have an mthfr polymorphism but you're not really at danger of getting anything and getting too much at all now would you want to go out any polar bear liver or seal liver probably not and i just i i kind of feel like i guess this is just the way this this type of discussion happens there's there's been discussion about this and there's even people who believe that vitamin a is toxic and i think you're gonna have to make a really strong case to even believe that something that's literally in a lot of different foods is actually toxic like humans never eat an egg yolk you know evolutionarily humans never ate liver when i was at the hodzin they literally treated the liver like it was made of gold they were just so careful with it and put it on and they distributed it but you know there's a tribe here of 50 people and all the men are going to get the liver and so they're all going to get maybe an ounce or half an ounce when they kill an animal and that's a big you know a big animal's liver so small amounts seem completely healthful and i'm not convinced at all that vitamin a is in any way toxic for humans it's just that it has a dose response curve and like anything too much can be harmful